Broken String Biosciences

Broken String Biosciences is a genomics company based at the Wellcome Genome Campus in Cambridge, England. The company focuses on improving the safety and effectiveness of gene editing therapies. It is supported by Illumina and Tencent and operates at the intersection of biology, bioinformatics, and data science. The company's proprietary technology, INDUCE-seq®, is a DNA break-mapping tool that helps drug developers assess the specificity of genome-editing tools and evaluate off-target genetic outcomes. This technology is crucial for characterizing genome breaks in cell and gene therapy applications and for discovering new therapeutic targets within the genome. Broken String is also collaborating with the Francis Crick Institute to explore genomic instability in amyotrophic lateral sclerosis (ALS) and is a member of the National Institute of Standards and Technology (NIST) Genome Editing Consortium, contributing to the development of safety testing standards for gene-editing therapies.